ea0011p305 | Diabetes, metabolism and cardiovascular | ECE2006
Drummond RS
, Koh-Tan HHC
, Brain NJR
, McClure JD
, Cherry LM
, Kirk AJB
, Sattar N
, Connell JMC
, Dominiczak AF
We hypothesised that SNPs within oxidative stress genes influence vascular compliance in patients with coronary artery disease.A SNP within the gene encoding the eNOS (NOS3) which encodes a Glu298→Asp amino acid substitution has been associated with cardiovascular disorders in which NO bioactivity is impaired. The gene coding for p22phox, a critical component of the NADH/NAD(P)H oxidase enzyme system, a major source of vascular SO, is CYB...